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CD47 blockade improves the therapeutic effect of osimertinib in non-small cell lung cancer

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 105-118 doi: 10.1007/s11684-022-0934-1

Abstract: This study aims to explore a rational combination strategy for enhancing the OSI efficacy.regulation by OSI and encourage the further exploration of combining anti-CD47 antibody with OSI as a new strategy

Keywords： osimertinib     anti-CD47 antibody     combination strategy     ADCP     EGFR    

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Circulating microRNAs in cardiovascular diseases: from biomarkers to therapeutic targets

Feng Wang,Chen Chen,Daowen Wang

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 404-418 doi: 10.1007/s11684-014-0379-2

Abstract: functions of circulating miRNAs in cardiovascular system but also inform the development of miRNAs therapeuticthe potential roles of circulating miRNAs in a variety of cardiovascular diseases from biomarkers to therapeutic

Keywords： microRNA     cardiovascular disease     biomarkers     therapeutic target    

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Brown and beige fat: the metabolic function, induction, and therapeutic potential

Shuwen Qian,Haiyan Huang,Qiqun Tang

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 162-172 doi: 10.1007/s11684-015-0382-2

Abstract: induce the development, the activation of brown or beige adipose tissue, which seem to be promising for therapeutic

Keywords： brown adipocyte     beige adipocyte     metabolism     obesity    

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Synchronous rectal adenocarcinoma and anal canal adenocarcinoma

GU Jin, YAO Yunfeng, LI Jiyou, LU Aiping, WANG Hongyi

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 333-337 doi: 10.1007/s11684-007-0064-9

Abstract: The therapeutic strategy for rectal and anal carcinoma is so different that it should be clearly identifiedis very important to differentiate the anorectal lesions pathologically because of the impact on the therapeutic

Keywords： CK7+/CK20+     resection     different     therapeutic strategy     upper-third    

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Molecular mechanisms and therapeutic strategies of vulnerable atherosclerotic plaques

Wen-Qiang CHEN MD, Yun ZHANG MD, PhD, FACC,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 36-42 doi: 10.1007/s11684-010-0020-y

Abstract: Vulnerable atherosclerotic plaque rupture leading to thrombosis is the major cause of acute coronary syndrome (ACS). Studies on the pathophysiologic mechanism of both ACS and plaque stabilizing treatment are driving the development of animal models of vulnerable plaque. In our laboratory, we established animal models of plaque rupture and thrombosis in rabbits and mice that are similar to human plaque rupture. Potential mechanisms involved in plaque vulnerability were studied from the inflammation-immunity, proliferation-apoptosis, oxidative stress and biomechanics aspects. Imaging markers and biomarkers were used to detect vulnerable plaques, including high frequency duplex ultrasound, intravascular ultrasound (IVUS), intravascular ultrasound elastography, magnetic resonance imaging (MRI) and inflammatory markers. Effective gene and drug strategies to treat vulnerable plaques were explored.

Keywords： vulnerable plaque     animal models     mechani-sm     detection     treatment    

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Advances in COVID-19: the virus, the pathogenesis, and evidence-based control and therapeutic strategies

Guangbiao Zhou, Saijuan Chen, Zhu Chen

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 117-125 doi: 10.1007/s11684-020-0773-x

Abstract: the insights in the virus, the responses of the host cells, the cytokine release syndrome, and the therapeutic

Keywords： COVID-19     SARS-CoV-2     pathogenesis     evidence-based medicine     control and therapeutic strategies    

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Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies

Peter B. Alexander,Xiao-Fan Wang

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 134-138 doi: 10.1007/s11684-015-0396-9

Abstract: of resistance to receptor tyrosine kinase inhibitors, which are the most prevalent class of targeted therapeutic

Keywords： targeted therapy     drug resistance     receptor tyrosine kinases     cancer    

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Triterpenoid inducers of Nrf2 signaling as potential therapeutic agents in sickle cell disease: a review

Amma Owusu-Ansah,Sung Hee Choi,Agne Petrosiute,John J. Letterio,Alex Yee-Chen Huang

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 46-56 doi: 10.1007/s11684-015-0375-1

Abstract: important intermediate in these pathophysiological processes and is therefore an important target for therapeuticexpression of anti-oxidant enzymes and is emerging as a protein whose function can be exploited with therapeuticThe article concludes with a perspective on the potential of the various therapeutic interventions to

Keywords： oxidative stress     Nrf2     triterpenoids     sickle cell disease     vaso-occlusion     CDDO-Me    

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Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic

Frontiers of Medicine doi: 10.1007/s11684-023-1050-6

Abstract: pancreatic cancer, encompassing its epidemiology, genomic characterization, risk factors, diagnosis, therapeuticthe primary mechanisms underlying treatment resistance in this malignancy, illustrating the latest therapeutic

Keywords： pancreatic cancer     cancer screening     single cell     molecular alterations     precancerous lesion     therapy resistance    

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Base editors: development and applications in biomedicine

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 359-387 doi: 10.1007/s11684-023-1013-y

Abstract: summarize their applications in the biomedical field, and discuss future perspectives and challenges for therapeutic

Keywords： base editing     CBE     ABE     ADAR     DdCBE     disease model     therapeutic application    

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AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

Megan A. Hatlen, Lan Wang, Stephen D. Nimer

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 248-262 doi: 10.1007/s11684-012-0206-6

Abstract: We also discuss potential therapeutic strategies for t(8;21) positive AML that involve targeting the

Keywords： AML1-ETO     mouse model     leukemia     t(8     21)     pathway hits     mutation     hematopoiesis     Kasumi-1     CD34+    

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Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases

Chong Liu, Dingfeng Su

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 35-40 doi: 10.1007/s11684-012-0171-0

Abstract:

Inflammation is important in the pathogenesis and development of cardiovascular diseases. Recent studies show that vagus nerve stimulation inhibits pro-inflammatory cytokine production through “the cholinergic anti-inflammatory pathway,” more specifically via the α7 nicotinic acetylcholine receptor (α7nAChR). In the current study, the role of the cholinergic anti-inflammatory pathway during septic shock, hypertension, and myocardial infarction is reviewed, and its possible clinical implications in cardiovascular diseases are discussed.

Keywords： α7 nicotinic acetylcholine receptor     cardiovascular diseases     baroreflex sensitivity    

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Observation on therapeutic efficacy of ursodeoxycholic acid in Chinese patients with primary biliary

Jiangyi Zhu, Yongquan Shi, Xinmin Zhou, Zengshan Li, Xiaofeng Huang, Zheyi Han, Jianhong Wang, Ruian Wang, Jie Ding, Kaichun Wu, Ying Han, Daiming Fan

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 255-263 doi: 10.1007/s11684-012-0227-1

Abstract: We aimed to assess the therapeutic effect of UDCA on Chinese patients with PBC.

Keywords： primary biliary cirrhosis     ursodeoxycholic acid     Chinese     biochemical response     therapeutic efficacy    

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Neutralizing monoclonal antibodies present new prospects to treat SARS-CoV-2 infections

Rongtao Lai, Tianhui Zhou, Xiaogang Xiang, Jie Lu, Haiguang Xin, Qing Xie

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 644-648 doi: 10.1007/s11684-021-0847-4

Abstract: Thus, new therapeutic strategies and effective vaccines are urgently needed to cope with this severeor more antibodies that recognize different regions of the viral surface may be the most effective therapeuticstrategy.

Keywords： neutralizing antibody     antibody cocktail     SARS-CoV-2     COVID-19     therapeutic strategy    

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Early diagnosis and therapeutic choice of

Jing LI, Ying FU, Ji-Yao WANG, Chuan-Tao TU, Xi-Zhong SHEN, Lei LI, Wei JIANG

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 308-316 doi: 10.1007/s11684-010-0103-9

Abstract: retained catheter, and aspiration plus antibiotics flushing and retained catheter), and corresponding therapeutic

Keywords： liver abscess     Klebsiella pneumoniae     computed tomography     therapy    

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Title Author Date Type Operation

CD47 blockade improves the therapeutic effect of osimertinib in non-small cell lung cancer

Journal Article

Circulating microRNAs in cardiovascular diseases: from biomarkers to therapeutic targets

Feng Wang,Chen Chen,Daowen Wang

Journal Article

Brown and beige fat: the metabolic function, induction, and therapeutic potential

Shuwen Qian,Haiyan Huang,Qiqun Tang

Journal Article

Synchronous rectal adenocarcinoma and anal canal adenocarcinoma

GU Jin, YAO Yunfeng, LI Jiyou, LU Aiping, WANG Hongyi

Journal Article

Molecular mechanisms and therapeutic strategies of vulnerable atherosclerotic plaques

Wen-Qiang CHEN MD, Yun ZHANG MD, PhD, FACC,

Journal Article

Advances in COVID-19: the virus, the pathogenesis, and evidence-based control and therapeutic strategies

Guangbiao Zhou, Saijuan Chen, Zhu Chen

Journal Article

Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies

Peter B. Alexander,Xiao-Fan Wang

Journal Article

Triterpenoid inducers of Nrf2 signaling as potential therapeutic agents in sickle cell disease: a review

Amma Owusu-Ansah,Sung Hee Choi,Agne Petrosiute,John J. Letterio,Alex Yee-Chen Huang

Journal Article

Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic

Journal Article

Base editors: development and applications in biomedicine

Journal Article

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

Megan A. Hatlen, Lan Wang, Stephen D. Nimer

Journal Article

Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases

Chong Liu, Dingfeng Su

Journal Article

Observation on therapeutic efficacy of ursodeoxycholic acid in Chinese patients with primary biliary

Jiangyi Zhu, Yongquan Shi, Xinmin Zhou, Zengshan Li, Xiaofeng Huang, Zheyi Han, Jianhong Wang, Ruian Wang, Jie Ding, Kaichun Wu, Ying Han, Daiming Fan

Journal Article

Neutralizing monoclonal antibodies present new prospects to treat SARS-CoV-2 infections

Rongtao Lai, Tianhui Zhou, Xiaogang Xiang, Jie Lu, Haiguang Xin, Qing Xie

Journal Article

Early diagnosis and therapeutic choice of

Jing LI, Ying FU, Ji-Yao WANG, Chuan-Tao TU, Xi-Zhong SHEN, Lei LI, Wei JIANG

Journal Article